Publikationer - Åsa Mackenzie

Increased sucrose consumption in mice gene-targeted for Vmat2 selectively in NeuroD6-positive neurons of the ventral tegmental area

Bimpisidis, Zisis; Serra, Gian Pietro; König, Niclas; Wallén-Mackenzie, Åsa

Ingår i Frontiers in Molecular Neuroscience, 2023.

DOI för Increased sucrose consumption in mice gene-targeted for Vmat2 selectively in NeuroD6-positive neurons of the ventral tegmental area Ladda ner fulltext (pdf) av Increased sucrose consumption in mice gene-targeted for Vmat2 selectively in NeuroD6-positive neurons of the ventral tegmental area

Improving well-being and survival in the 6-OHDA lesion model of Parkinson´s disease in mice: Literature review and step-by-step protocol

Guillaumin, Adriane; Vlcek, Bianca; Wallén-Mackenzie, Åsa

Ingår i Scandinavian Journal of Laboratory Animal Science, s. 1-21, 2022.

DOI för Improving well-being and survival in the 6-OHDA lesion model of Parkinson´s disease in mice: Literature review and step-by-step protocol

Experimental investigation into the role of the subthalamic nucleus (STN) in motor control using optogenetics in mice

Guillaumin, Adriane; Serra, Gian Pietro; Georges, Francois; Wallén-Mackenzie, Åsa

Ingår i Brain Research, 2021.

DOI för Experimental investigation into the role of the subthalamic nucleus (STN) in motor control using optogenetics in mice Ladda ner fulltext (pdf) av Experimental investigation into the role of the subthalamic nucleus (STN) in motor control using optogenetics in mice

Midbrain Dopamine Neurons Defined by TrpV1 Modulate Psychomotor Behavior

Serra, Gian Pietro; Guillaumin, Adriane; Dumas, Sylvie; Vlcek, Bianca et al.

Ingår i Frontiers in Neural Circuits, 2021.

DOI för Midbrain Dopamine Neurons Defined by TrpV1 Modulate Psychomotor Behavior Ladda ner fulltext (pdf) av Midbrain Dopamine Neurons Defined by TrpV1 Modulate Psychomotor Behavior

DNA methylation of Vesicular Glutamate Transporters in the mesocorticolimbic brain following early-life stress and adult ethanol exposure-an explorative study

Vrettou, Maria; Yan, Liying; Nilsson, Kent W.; Wallén-Mackenzie, Åsa et al.

Ingår i Scientific Reports, 2021.

DOI för DNA methylation of Vesicular Glutamate Transporters in the mesocorticolimbic brain following early-life stress and adult ethanol exposure-an explorative study Ladda ner fulltext (pdf) av DNA methylation of Vesicular Glutamate Transporters in the mesocorticolimbic brain following early-life stress and adult ethanol exposure-an explorative study

Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse

Bimpisidis, Zisis; König, Niclas; Wallén-Mackenzie, Åsa

Ingår i Journal of Visualized Experiments, 2020.

DOI för Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse Ladda ner fulltext (pdf) av Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse

Selective Knockout of the Vesicular Monoamine Transporter 2 (Vmat2) Gene in Calbindin2/Calretinin-Positive Neurons Results in Profound Changes in Behavior and Response to Drugs of Abuse

König, Niclas; Bimpisidis, Zisis; Dumas, Sylvie; Wallén-Mackenzie, Åsa

Ingår i Frontiers in Behavioral Neuroscience, 2020.

DOI för Selective Knockout of the Vesicular Monoamine Transporter 2 (Vmat2) Gene in Calbindin2/Calretinin-Positive Neurons Results in Profound Changes in Behavior and Response to Drugs of Abuse Ladda ner fulltext (pdf) av Selective Knockout of the Vesicular Monoamine Transporter 2 (Vmat2) Gene in Calbindin2/Calretinin-Positive Neurons Results in Profound Changes in Behavior and Response to Drugs of Abuse

Spatio-molecular domains identified in the mouse subthalamic nucleus and neighboring glutamatergic and GABAergic brain structures

Wallén-Mackenzie, Åsa; Dumas, Sylvie; Papathanou, Maria; Martis Thiele, Michaela et al.

Ingår i Communications Biology, 2020.

DOI för Spatio-molecular domains identified in the mouse subthalamic nucleus and neighboring glutamatergic and GABAergic brain structures Ladda ner fulltext (pdf) av Spatio-molecular domains identified in the mouse subthalamic nucleus and neighboring glutamatergic and GABAergic brain structures

The NeuroD6 Subtype of VTA Neurons Contributes to Psychostimulant Sensitization and Behavioral Reinforcement

Bimpisidis, Zisis; König, Niclas; Stagkourakis, Stefanos; Zell, Vivien et al.

Ingår i eNeuro, 2019.

DOI för The NeuroD6 Subtype of VTA Neurons Contributes to Psychostimulant Sensitization and Behavioral Reinforcement Ladda ner fulltext (pdf) av The NeuroD6 Subtype of VTA Neurons Contributes to Psychostimulant Sensitization and Behavioral Reinforcement

Off-Target Effects in Transgenic Mice: Characterization of Dopamine Transporter (DAT)-Cre Transgenic Mouse Lines Exposes Multiple Non-Dopaminergic Neuronal Clusters Available for Selective Targeting within Limbic Neurocircuitry

Papathanou, Maria; Dumas, Sylvie; Pettersson, Hanna; Olson, Lars et al.

Ingår i eNeuro, 2019.

DOI för Off-Target Effects in Transgenic Mice: Characterization of Dopamine Transporter (DAT)-Cre Transgenic Mouse Lines Exposes Multiple Non-Dopaminergic Neuronal Clusters Available for Selective Targeting within Limbic Neurocircuitry Ladda ner fulltext (pdf) av Off-Target Effects in Transgenic Mice: Characterization of Dopamine Transporter (DAT)-Cre Transgenic Mouse Lines Exposes Multiple Non-Dopaminergic Neuronal Clusters Available for Selective Targeting within Limbic Neurocircuitry

Developmental Co-expression of Vglut2 and Nurr1 in a Mes-Di-Encephalic Continuum Preceeds Dopamine and Glutamate Neuron Specification

Dumas, Sylvie; Wallén-Mackenzie, Åsa

Ingår i Frontiers in Cell and Developmental Biology, 2019.

DOI för Developmental Co-expression of Vglut2 and Nurr1 in a Mes-Di-Encephalic Continuum Preceeds Dopamine and Glutamate Neuron Specification Ladda ner fulltext (pdf) av Developmental Co-expression of Vglut2 and Nurr1 in a Mes-Di-Encephalic Continuum Preceeds Dopamine and Glutamate Neuron Specification

VGLUT2 rs2290045 genotype moderates environmental sensitivity to alcohol-related problems in three samples of youths

Vrettou, Maria; Nilsson, Kent W.; Tuvblad, Catherine; Rehn, Mattias et al.

Ingår i European Child and Adolescent Psychiatry, s. 1329-1340, 2019.

DOI för VGLUT2 rs2290045 genotype moderates environmental sensitivity to alcohol-related problems in three samples of youths Ladda ner fulltext (pdf) av VGLUT2 rs2290045 genotype moderates environmental sensitivity to alcohol-related problems in three samples of youths

Neurocircuitry of Reward and Addiction: Potential Impact of Dopamine-Glutamate Co-release as Future Target in Substance Use Disorder

Bimpisidis, Zisis; Wallén-Mackenzie, Åsa

Ingår i Journal of Clinical Medicine, 2019.

DOI för Neurocircuitry of Reward and Addiction: Potential Impact of Dopamine-Glutamate Co-release as Future Target in Substance Use Disorder Ladda ner fulltext (pdf) av Neurocircuitry of Reward and Addiction: Potential Impact of Dopamine-Glutamate Co-release as Future Target in Substance Use Disorder

Validated multi‐step approach for in vivo recording and analysis of optogenetically evoked glutamate in the mouse globus pallidus

Viereckel, Thomas; Konradsson-Geuken, Åsa; Wallén-Mackenzie, Åsa

Ingår i Journal of Neurochemistry, s. 125-138, 2018.

DOI för Validated multi‐step approach for in vivo recording and analysis of optogenetically evoked glutamate in the mouse globus pallidus

Targeting VGLUT2 in Mature Dopamine Neurons Decreases Mesoaccumbal Glutamatergic Transmission and Identifies a Role for Glutamate Co-release in Synaptic Plasticity by Increasing Baseline AMPA/NMDA Ratio

Papathanou, Maria; Creed, Meaghan; Dorst, Matthijs; Bimpisidis, Zisis et al.

Ingår i Frontiers in Neural Circuits, s. 1-20, 2018.

DOI för Targeting VGLUT2 in Mature Dopamine Neurons Decreases Mesoaccumbal Glutamatergic Transmission and Identifies a Role for Glutamate Co-release in Synaptic Plasticity by Increasing Baseline AMPA/NMDA Ratio Ladda ner fulltext (pdf) av Targeting VGLUT2 in Mature Dopamine Neurons Decreases Mesoaccumbal Glutamatergic Transmission and Identifies a Role for Glutamate Co-release in Synaptic Plasticity by Increasing Baseline AMPA/NMDA Ratio

Vgluts In The Mesocorticolimbic Brain Of Adolescent Outbred Rats Exposed To Alcohol And Nicotine

Vrettou, Maria; Nordenankar, Karin; Segerström, Lova; Wallén-Mackenzie, Åsa et al.

Ingår i Alcohol and Alcoholism, 2017.

Ethanol affects limbic and striatal presynaptic glutamatergic and DNA methylation gene expression in outbred rats exposed to early-life stress

Vrettou, Maria; Granholm, Linnea; Todkar, Aniruddha; Nilsson, Kent W. et al.

Ingår i Addiction Biology, s. 369-380, 2017.

DOI för Ethanol affects limbic and striatal presynaptic glutamatergic and DNA methylation gene expression in outbred rats exposed to early-life stress

A Physiological Insight into Real-Time Glutamate Release upon Optogenetic Stimulation in vivo

Viereckel, Thomas; Konradsson-Geuken, Åsa; Wallén-Mackenzie, Åsa

2017.

Disrupting Glutamate Co-transmission Does Not Affect Acquisition of Conditioned Behavior Reinforced by Dopamine Neuron Activation

Wang, Dong V.; Viereckel, Thomas; Zell, Vivien; Konradsson-Geuken, Åsa et al.

Ingår i Cell reports, s. 2584-2591, 2017.

DOI för Disrupting Glutamate Co-transmission Does Not Affect Acquisition of Conditioned Behavior Reinforced by Dopamine Neuron Activation Ladda ner fulltext (pdf) av Disrupting Glutamate Co-transmission Does Not Affect Acquisition of Conditioned Behavior Reinforced by Dopamine Neuron Activation

VGLUT2 genotype interacts with environmental experiences to predict alcohol misuse in young adults

Vrettou, Maria; Nillson, Kent W.; Tuvblad, Catherine; Rehn, Mattias et al.

2016.

Reduced Vglut2/Slc17a6 Gene Expression Levels throughout the Mouse Subthalamic Nucleus Cause Cell Loss and Structural Disorganization Followed by Increased Motor Activity and Decreased Sugar Consumption

Schweizer, Nadine; Viereckel, Thomas; Smith-Anttila, Casey J. A.; Nordenankar, Karin et al.

Ingår i eNeuro, 2016.

DOI för Reduced Vglut2/Slc17a6 Gene Expression Levels throughout the Mouse Subthalamic Nucleus Cause Cell Loss and Structural Disorganization Followed by Increased Motor Activity and Decreased Sugar Consumption

Midbrain Gene Screening Identifies a New Mesoaccumbal Glutamatergic Pathway and a Marker for Dopamine Cells Neuroprotected in Parkinson's Disease

Viereckel, Thomas; Dumas, Sylvie; Smith-Anttila, Casey J. A.; Vlcek, Bianca et al.

Ingår i Scientific Reports, 2016.

DOI för Midbrain Gene Screening Identifies a New Mesoaccumbal Glutamatergic Pathway and a Marker for Dopamine Cells Neuroprotected in Parkinson's Disease Ladda ner fulltext (pdf) av Midbrain Gene Screening Identifies a New Mesoaccumbal Glutamatergic Pathway and a Marker for Dopamine Cells Neuroprotected in Parkinson's Disease

In Situ Proximity Ligation Assay (PLA)

Bagchi, Sonchita; Fredriksson, Robert; Wallén-Mackenzie, Åsa

Ingår i ELISA, s. 149-159, 2015.

DOI för In Situ Proximity Ligation Assay (PLA)

Reply to Konsolaki and Skaliora: Habituation, hyperlocomotion, and "genuine hyperlocomotion"

Pupe, Stefano; Schweizer, Nadine; Wallen-Mackenzie, Åsa

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. E5-E5, 2015.

DOI för Reply to Konsolaki and Skaliora: Habituation, hyperlocomotion, and "genuine hyperlocomotion"

Increased hippocampal excitability and impaired spatial memory function in mice lacking VGLUT2 selectively in neurons defined by tyrosine hydroxylase promoter activity

Nordenankar, Karin; Smith-Anttila, Casey J A; Schweizer, Nadine; Viereckel, Thomas et al.

Ingår i Brain Structure and Function, s. 2171-2190, 2015.

DOI för Increased hippocampal excitability and impaired spatial memory function in mice lacking VGLUT2 selectively in neurons defined by tyrosine hydroxylase promoter activity Ladda ner fulltext (pdf) av Increased hippocampal excitability and impaired spatial memory function in mice lacking VGLUT2 selectively in neurons defined by tyrosine hydroxylase promoter activity

Targeted deletion of Vglut2 expression in the embryonal telencephalon promotes an anxiolytic phenotype of the adult mouse

Nordenankar, Karin; Bergfors, Assar; Wallén-Mackenzie, Åsa

Ingår i Upsala Journal of Medical Sciences, 2015.

DOI för Targeted deletion of Vglut2 expression in the embryonal telencephalon promotes an anxiolytic phenotype of the adult mouse Ladda ner fulltext (pdf) av Targeted deletion of Vglut2 expression in the embryonal telencephalon promotes an anxiolytic phenotype of the adult mouse

Ethanol Affects Limbic and Striatal Expression of Vesicular Glutamate Transporters in Outbred Rats Exposed to Early Life Stress

Vrettou, Maria; Granholm, Linnea; Todkar, Aniruddha; Nilsson, Kent W. et al.

Ingår i Alcohol and Alcoholism, 2015.

Cre-driven optogenetics in the heterogeneous genetic panorama of the VTA

Pupe, Stefano; Wallén-Mackenzie, Åsa

Ingår i TINS - Trends in Neurosciences, s. 375-386, 2015.

DOI för Cre-driven optogenetics in the heterogeneous genetic panorama of the VTA

SLC10A4 Is a Vesicular Amine-Associated Transporter Modulating Dopamine Homeostasis

Larhammar, Martin; Patra, Kalicharan; Blunder, Martina; Emilsson, Lina et al.

Ingår i Biological Psychiatry, s. 526-536, 2015.

DOI för SLC10A4 Is a Vesicular Amine-Associated Transporter Modulating Dopamine Homeostasis

Haplotype-tag single nucleotide polymorphism analysis of the Vesicular Glutamate Transporter (VGLUT) genes in severely alcoholic women

Comasco, Erika; Hallman, Jarmila; Wallen-Mackenzie, Åsa

Ingår i Psychiatry Research, s. 403-405, 2014.

DOI för Haplotype-tag single nucleotide polymorphism analysis of the Vesicular Glutamate Transporter (VGLUT) genes in severely alcoholic women

Reduced Gene Expression Levels of Munc13-1 and Additional Components of the Presynaptic Exocytosis Machinery Upon Conditional Targeting of Vglut2 in the Adolescent Mouse

Rajagopalan, Aparna; Schweizer, Nadine; Nordenankar, Karin; Jahan, Sultana Nilufar et al.

Ingår i Synapse, s. 624-633, 2014.

DOI för Reduced Gene Expression Levels of Munc13-1 and Additional Components of the Presynaptic Exocytosis Machinery Upon Conditional Targeting of Vglut2 in the Adolescent Mouse

The multilingual nature of dopamine neurons

Trudeau, Louis-Eric; Hnasko, Thomas S.; Wallén-Mackenzie, Åsa; Morales, Marisela et al.

Ingår i Dopamine, s. 141-164, 2014.

DOI för The multilingual nature of dopamine neurons

Limiting glutamate transmission in a Vglut2-expressing subpopulation of the subthalamic nucleus is sufficient to cause hyperlocomotion

Schweizer, Nadine; Pupe, Stefano; Arvidsson, Emma; Nordenankar, Karin et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 7837-7842, 2014.

DOI för Limiting glutamate transmission in a Vglut2-expressing subpopulation of the subthalamic nucleus is sufficient to cause hyperlocomotion

Age- and Sex-Dependence of Dopamine Release and Capacity for Recovery Identified in the Dorsal Striatum ofC57/Bl6J Mice

Arvidsson, Emma; Viereckel, Thomas; Mikulovic, Sanja; Wallén-Mackenzie, Åsa

Ingår i PLOS ONE, s. e99592-, 2014.

DOI för Age- and Sex-Dependence of Dopamine Release and Capacity for Recovery Identified in the Dorsal Striatum ofC57/Bl6J Mice Ladda ner fulltext (pdf) av Age- and Sex-Dependence of Dopamine Release and Capacity for Recovery Identified in the Dorsal Striatum ofC57/Bl6J Mice

Glutamate corelease promotes growth and survival of midbrain dopamine neurons

Fortin, G. M.; Bourque, M. -J; Mendez, J. A.; Leo, D. et al.

Ingår i Journal of Neuroscience, s. 17477-17491, 2012.

DOI för Glutamate corelease promotes growth and survival of midbrain dopamine neurons

Ultrastructural characterization of the mesostriatal dopamine innervation in mice, including two mouse lines of conditional VGLUT2 knockout in dopamine neurons

Berube-Carriere, Noemie; Guay, Ginette; Fortin, Guillaume M.; Kullander, Klas et al.

Ingår i European Journal of Neuroscience, s. 527-538, 2012.

DOI för Ultrastructural characterization of the mesostriatal dopamine innervation in mice, including two mouse lines of conditional VGLUT2 knockout in dopamine neurons

Haplotype tag single-nucleotide polymorphism analysis of the vesicular glutamate transporter 2 gene in severe alcoholism among women

Comasco, Erika; Oreland, Lars; Hallman, Jarmila; Wallen-Mackenzie, Åsa

Ingår i European Neuropsychopharmacology, s. S397-S397, 2012.

DOI för Haplotype tag single-nucleotide polymorphism analysis of the vesicular glutamate transporter 2 gene in severe alcoholism among women

Targeting VGLUT2 in dopamine neurons affects the brain reward system

Wallen-Mackenzie, Åsa; Arvidsson, Emma; Restrepo, Ernesto; Johann, Stefano Pupe et al.

Ingår i European Neuropsychopharmacology, s. S128-S129, 2012.

DOI för Targeting VGLUT2 in dopamine neurons affects the brain reward system

From glutamate co-release to vesicular synergy: vesicular glutamate transporters

El Mestikawy, Salah; Wallén-Mackenzie, Åsa; Fortin, Guillaume M.; Descarries, Laurent et al.

Ingår i Nature Reviews Neuroscience, s. 204-216, 2011.

DOI för From glutamate co-release to vesicular synergy: vesicular glutamate transporters

A sensory subpopulation depends on vesicular glutamate transporter 2 for mechanical pain, and together with substance P, inflammatory pain

Lagerström, Malin C.; Rogoz, Katarzyna; Abrahamsen, Bjarke; Lind, Anne-Li et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 5789-5794, 2011.

DOI för A sensory subpopulation depends on vesicular glutamate transporter 2 for mechanical pain, and together with substance P, inflammatory pain

Enhanced Sucrose and Cocaine Self-Administration and Cue-Induced Drug Seeking after Loss of VGLUT2 in Midbrain Dopamine Neurons in Mice

Alsiö, Johan; Nordenankar, Karin; Arvidsson, Emma; Birgner, Carolina et al.

Ingår i Journal of Neuroscience, s. 12593-12603, 2011.

DOI för Enhanced Sucrose and Cocaine Self-Administration and Cue-Induced Drug Seeking after Loss of VGLUT2 in Midbrain Dopamine Neurons in Mice

Genetic inactivation of the vesicular glutamate transporter 2 (VGLUT2) in the mouse: what have we learnt about functional glutamatergic neurotransmission?

Wallén-Mackenzie, Åsa; Wootz, Hanna; Englund, Hillevi

Ingår i Upsala Journal of Medical Sciences, s. 11-20, 2010.

DOI för Genetic inactivation of the vesicular glutamate transporter 2 (VGLUT2) in the mouse: what have we learnt about functional glutamatergic neurotransmission?

VGLUT2-Dependent Sensory Neurons in the TRPV1 Population Regulate Pain and Itch

Lagerström, Malin C.; Rogoz, Katarzyna; Abrahamsen, Bjarke; Persson, Emma et al.

Ingår i Neuron, s. 529-542, 2010.

DOI för VGLUT2-Dependent Sensory Neurons in the TRPV1 Population Regulate Pain and Itch

VGLUT2 in dopamine neurons is required for psychostimulant-induced behavioural activation

Birgner, Carolina; Nordenankar, Karin; Lundblad, Martin; Mendez, José Alfredo et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 389-394, 2010.

DOI för VGLUT2 in dopamine neurons is required for psychostimulant-induced behavioural activation

Reduced VGLUT2 expression increases motor neuron viability in Sod1(G93A) mice

Wootz, Hanna; Enjin, Anders; Wallen-Mackenzie, Åsa; Lindholm, Dan et al.

Ingår i Neurobiology of Disease, s. 58-66, 2010.

DOI för Reduced VGLUT2 expression increases motor neuron viability in Sod1(G93A) mice

Restricted cortical and amygdaloid removal of vesicular glutamate transporter 2 in preadolescent mice impacts dopaminergic activity and neuronal circuitry of higher brain function

Wallén-Mackenzie, Åsa; Nordenankar, Karin; Fejgin, Kim; Lagerström, Malin C et al.

Ingår i Journal of Neuroscience, s. 2238-2251, 2009.

DOI för Restricted cortical and amygdaloid removal of vesicular glutamate transporter 2 in preadolescent mice impacts dopaminergic activity and neuronal circuitry of higher brain function

VGLUT2 is essential in neuronal circuitry of cognitive and emotional behavior

Mackenzie, Åsa; Fejgin, Kim; Lagerström, Malin C; Nordenankar, Karin et al.

Ingår i Society for Neuroscience Abstract Viewer and Itinerary Planner, 2008.

Vesicular glutamate transporter 2 is required for central respiratory rhythm generation but not for locomotor central pattern generation

Wallén-Mackenzie, Åsa; Gezelius, Henrik; Thoby-Brisson, Muriel; Nygård, Anna et al.

Ingår i Journal of Neuroscience, s. 12294-12307, 2006.

DOI för Vesicular glutamate transporter 2 is required for central respiratory rhythm generation but not for locomotor central pattern generation

Role of glutamate in locomotor rhythm generating neuronal circuitry

Gezelius, Henrik; Wallén-Mackenzie, Åsa; Enjin, Anders; Lagerström, Malin et al.

Ingår i Journal of Physiology - Paris, s. 297-303, 2006.

DOI för Role of glutamate in locomotor rhythm generating neuronal circuitry

Effects of prenatal fluoxetine on serotonergic cell number in the dorsal raphe lateral wing

Wargelius, Hanna-Linn; Deneris, Evan; Mackenzie, Åsa; Oreland, Lars