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MSc research projects: Identifying and characterising causal genes for
cardiometabolic diseases using systematic image- and CRISPR-based
screens in zebrafish model systems

The den Hoed lab at IGP’s Medical Genetics and Genomics section and SciLifeLab
is looking for motivated MSc students for degree projects. The project work will
be based at the BMC in Uppsala. Background information and a description of the
research program can be found below. The topic of individual research projects
will depend on the student’s interests and the requirements of the program at the
time of applying.

Description of the research program
Genome-wide association studies (GWAS) have identified hundreds of genetic loci
that are robustly associated with cardiovascular and metabolic risk factors and
diseases, such as blood glucose, insulin and lipid levels, type 2 diabetes,
atherosclerosis, and coronary heart disease. With few exceptions, the causal
genes in these loci remain uncharacterised, and in many cases even unidentified.
Before results from GWAS can be translated into efficient new medication, we
need to identify and characterise the causal genes. Recent developments in
CRISPR-Cas9-based mutagenesis; automated, in vivo imaging; and image-based
quantification have highlighted the zebrafish as a promising model system for
large-scale genetic screens.

In recent years, our group developed and validated high-throughput,
largely image-based translational approaches to identify and characterise causal
genes for cardiometabolic risk factors and diseases using zebrafish model
systems. Besides being able to work with state-of-the-art approaches, we provide
students with the opportunity to be part of a multidisciplinary and international
research team.

Requirements MSc students
We are looking for enthusiastic, motivated students that are eligible for a ≥30
ECTS project. Students should enjoy working as part of a team but be able to
also work independently after receiving adequate instructions. Ideally, candidates
have some previous practical experience in working with molecular biological
methods.

Please send us a short description of your relevant work experience, your CV and
your motivation for being interested in doing a research project with us. Please
also indicate the period during which you are available.

Marcel den Hoed
http://igp.uu.se/forskning/genetik_genomik/marcel-den-hoed/
marcel.den_hoed@igp.uu.se

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