Our Research groups
We are interested in understanding how the brain processes incoming information (cues) and transforms this into a relevant behavioural output, a motivated or goal-directed behaviour. The ventral tegmental area (VTA) and the subthalamic nucleus (STN) have emerged as two key regulatory areas for processing emotional and motional information. Our hypothesis is that their involvement in the regulation of a range of different behaviours is enabled by the actions of different subpopulations within these areas. We work with unravelling such subpopulations and identifying their functional roles in neurocircuitry activity and behavioural output. Dopamine- and glutamate-signalling neurons, as well as dopamine/glutamate co-signaling neurons, are at the core of our work. We use electrochemical, electrophysiological, behavioural, anatomical and molecular methods, in combination with pharmacological and/or optogenetic approaches. Our research goal is to advance the preclinical knowledge around affective disorders such as substance dependence, and motor dysfunction as seen in tremor disorders, including Parkinson´s disease.
Our research aims to understand which factors are involved in triggering the onset of early sexual maturation in salmonids, and how they are regulated. Understanding the signalling pathways involved in the onset of maturation in fish will provide tools to develop more sustainable hatchery programs.
Söderhäll Lab – Invertebrate Immunity
Invertebrate animals lack an adaptive immune system and they have to rely on very efficient non-adaptative or innate immune systems to deal with all pathogens they are challenged with. This innate immune system and its constituting factors are studied using both biochemical and molecular techniques. Of interest for our research is also to study the phylogeny of certain immune genes.