Publications - Åsa Mackenzie

Increased sucrose consumption in mice gene-targeted for Vmat2 selectively in NeuroD6-positive neurons of the ventral tegmental area

Bimpisidis, Zisis; Serra, Gian Pietro; König, Niclas; Wallén-Mackenzie, Åsa

Part of Frontiers in Molecular Neuroscience, 2023.

DOI for Increased sucrose consumption in mice gene-targeted for Vmat2 selectively in NeuroD6-positive neurons of the ventral tegmental area Download full text (pdf) of Increased sucrose consumption in mice gene-targeted for Vmat2 selectively in NeuroD6-positive neurons of the ventral tegmental area

Improving well-being and survival in the 6-OHDA lesion model of Parkinson's disease in mice: Literature review and step-by-step protocol

Guillaumin, Adriane; Vlcek, Bianca; Wallén-Mackenzie, Åsa

Part of Scandinavian Journal of Laboratory Animal Science, p. 1-21, 2022.

Improving well-being and survival in the 6-OHDA lesion model of Parkinson acute accent s disease in mice: Literature review and step-by-step protocol

Guillaumin, Adriane; Vlcek, Bianca; Wallén-Mackenzie, Åsa

Part of Scandinavian Journal of Laboratory Animal Science, p. 1-21, 2022.

Experimental investigation into the role of the subthalamic nucleus (STN) in motor control using optogenetics in mice

Guillaumin, Adriane; Serra, Gian Pietro; Georges, Francois; Wallén-Mackenzie, Åsa

Part of Brain Research, 2021.

DOI for Experimental investigation into the role of the subthalamic nucleus (STN) in motor control using optogenetics in mice Download full text (pdf) of Experimental investigation into the role of the subthalamic nucleus (STN) in motor control using optogenetics in mice

Midbrain Dopamine Neurons Defined by TrpV1 Modulate Psychomotor Behavior

Serra, Gian Pietro; Guillaumin, Adriane; Dumas, Sylvie; Vlcek, Bianca et al.

Part of Frontiers in Neural Circuits, 2021.

DOI for Midbrain Dopamine Neurons Defined by TrpV1 Modulate Psychomotor Behavior Download full text (pdf) of Midbrain Dopamine Neurons Defined by TrpV1 Modulate Psychomotor Behavior

DNA methylation of Vesicular Glutamate Transporters in the mesocorticolimbic brain following early-life stress and adult ethanol exposure-an explorative study

Vrettou, Maria; Yan, Liying; Nilsson, Kent W.; Wallén-Mackenzie, Åsa et al.

Part of Scientific Reports, 2021.

DOI for DNA methylation of Vesicular Glutamate Transporters in the mesocorticolimbic brain following early-life stress and adult ethanol exposure-an explorative study Download full text (pdf) of DNA methylation of Vesicular Glutamate Transporters in the mesocorticolimbic brain following early-life stress and adult ethanol exposure-an explorative study

Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse

Bimpisidis, Zisis; König, Niclas; Wallén-Mackenzie, Åsa

Part of Journal of Visualized Experiments, 2020.

DOI for Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse Download full text (pdf) of Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse

Selective Knockout of the Vesicular Monoamine Transporter 2 (Vmat2) Gene in Calbindin2/Calretinin-Positive Neurons Results in Profound Changes in Behavior and Response to Drugs of Abuse

König, Niclas; Bimpisidis, Zisis; Dumas, Sylvie; Wallén-Mackenzie, Åsa

Part of Frontiers in Behavioral Neuroscience, 2020.

DOI for Selective Knockout of the Vesicular Monoamine Transporter 2 (Vmat2) Gene in Calbindin2/Calretinin-Positive Neurons Results in Profound Changes in Behavior and Response to Drugs of Abuse Download full text (pdf) of Selective Knockout of the Vesicular Monoamine Transporter 2 (Vmat2) Gene in Calbindin2/Calretinin-Positive Neurons Results in Profound Changes in Behavior and Response to Drugs of Abuse

Spatio-molecular domains identified in the mouse subthalamic nucleus and neighboring glutamatergic and GABAergic brain structures

Wallén-Mackenzie, Åsa; Dumas, Sylvie; Papathanou, Maria; Martis Thiele, Michaela et al.

Part of Communications Biology, 2020.

DOI for Spatio-molecular domains identified in the mouse subthalamic nucleus and neighboring glutamatergic and GABAergic brain structures Download full text (pdf) of Spatio-molecular domains identified in the mouse subthalamic nucleus and neighboring glutamatergic and GABAergic brain structures

The NeuroD6 Subtype of VTA Neurons Contributes to Psychostimulant Sensitization and Behavioral Reinforcement

Bimpisidis, Zisis; König, Niclas; Stagkourakis, Stefanos; Zell, Vivien et al.

Part of eNeuro, 2019.

DOI for The NeuroD6 Subtype of VTA Neurons Contributes to Psychostimulant Sensitization and Behavioral Reinforcement Download full text (pdf) of The NeuroD6 Subtype of VTA Neurons Contributes to Psychostimulant Sensitization and Behavioral Reinforcement

Off-Target Effects in Transgenic Mice: Characterization of Dopamine Transporter (DAT)-Cre Transgenic Mouse Lines Exposes Multiple Non-Dopaminergic Neuronal Clusters Available for Selective Targeting within Limbic Neurocircuitry

Papathanou, Maria; Dumas, Sylvie; Pettersson, Hanna; Olson, Lars et al.

Part of eNeuro, 2019.

DOI for Off-Target Effects in Transgenic Mice: Characterization of Dopamine Transporter (DAT)-Cre Transgenic Mouse Lines Exposes Multiple Non-Dopaminergic Neuronal Clusters Available for Selective Targeting within Limbic Neurocircuitry Download full text (pdf) of Off-Target Effects in Transgenic Mice: Characterization of Dopamine Transporter (DAT)-Cre Transgenic Mouse Lines Exposes Multiple Non-Dopaminergic Neuronal Clusters Available for Selective Targeting within Limbic Neurocircuitry

Developmental Co-expression of Vglut2 and Nurr1 in a Mes-Di-Encephalic Continuum Preceeds Dopamine and Glutamate Neuron Specification

Dumas, Sylvie; Wallén-Mackenzie, Åsa

Part of Frontiers in Cell and Developmental Biology, 2019.

DOI for Developmental Co-expression of Vglut2 and Nurr1 in a Mes-Di-Encephalic Continuum Preceeds Dopamine and Glutamate Neuron Specification Download full text (pdf) of Developmental Co-expression of Vglut2 and Nurr1 in a Mes-Di-Encephalic Continuum Preceeds Dopamine and Glutamate Neuron Specification

VGLUT2 rs2290045 genotype moderates environmental sensitivity to alcohol-related problems in three samples of youths

Vrettou, Maria; Nilsson, Kent W.; Tuvblad, Catherine; Rehn, Mattias et al.

Part of European Child and Adolescent Psychiatry, p. 1329-1340, 2019.

DOI for VGLUT2 rs2290045 genotype moderates environmental sensitivity to alcohol-related problems in three samples of youths Download full text (pdf) of VGLUT2 rs2290045 genotype moderates environmental sensitivity to alcohol-related problems in three samples of youths

Neurocircuitry of Reward and Addiction: Potential Impact of Dopamine-Glutamate Co-release as Future Target in Substance Use Disorder

Bimpisidis, Zisis; Wallén-Mackenzie, Åsa

Part of Journal of Clinical Medicine, 2019.

DOI for Neurocircuitry of Reward and Addiction: Potential Impact of Dopamine-Glutamate Co-release as Future Target in Substance Use Disorder Download full text (pdf) of Neurocircuitry of Reward and Addiction: Potential Impact of Dopamine-Glutamate Co-release as Future Target in Substance Use Disorder

Validated multi‐step approach for in vivo recording and analysis of optogenetically evoked glutamate in the mouse globus pallidus

Viereckel, Thomas; Konradsson-Geuken, Åsa; Wallén-Mackenzie, Åsa

Part of Journal of Neurochemistry, p. 125-138, 2018.

DOI for Validated multi‐step approach for in vivo recording and analysis of optogenetically evoked glutamate in the mouse globus pallidus

Targeting VGLUT2 in Mature Dopamine Neurons Decreases Mesoaccumbal Glutamatergic Transmission and Identifies a Role for Glutamate Co-release in Synaptic Plasticity by Increasing Baseline AMPA/NMDA Ratio

Papathanou, Maria; Creed, Meaghan; Dorst, Matthijs; Bimpisidis, Zisis et al.

Part of Frontiers in Neural Circuits, p. 1-20, 2018.

DOI for Targeting VGLUT2 in Mature Dopamine Neurons Decreases Mesoaccumbal Glutamatergic Transmission and Identifies a Role for Glutamate Co-release in Synaptic Plasticity by Increasing Baseline AMPA/NMDA Ratio Download full text (pdf) of Targeting VGLUT2 in Mature Dopamine Neurons Decreases Mesoaccumbal Glutamatergic Transmission and Identifies a Role for Glutamate Co-release in Synaptic Plasticity by Increasing Baseline AMPA/NMDA Ratio

Vgluts In The Mesocorticolimbic Brain Of Adolescent Outbred Rats Exposed To Alcohol And Nicotine

Vrettou, Maria; Nordenankar, Karin; Segerström, Lova; Wallén-Mackenzie, Åsa et al.

Part of Alcohol and Alcoholism, 2017.

Ethanol affects limbic and striatal presynaptic glutamatergic and DNA methylation gene expression in outbred rats exposed to early-life stress

Vrettou, Maria; Granholm, Linnea; Todkar, Aniruddha; Nilsson, Kent W. et al.

Part of Addiction Biology, p. 369-380, 2017.

DOI for Ethanol affects limbic and striatal presynaptic glutamatergic and DNA methylation gene expression in outbred rats exposed to early-life stress

A Physiological Insight into Real-Time Glutamate Release upon Optogenetic Stimulation in vivo

Viereckel, Thomas; Konradsson-Geuken, Åsa; Wallén-Mackenzie, Åsa

2017.

Disrupting Glutamate Co-transmission Does Not Affect Acquisition of Conditioned Behavior Reinforced by Dopamine Neuron Activation

Wang, Dong V.; Viereckel, Thomas; Zell, Vivien; Konradsson-Geuken, Åsa et al.

Part of Cell reports, p. 2584-2591, 2017.

DOI for Disrupting Glutamate Co-transmission Does Not Affect Acquisition of Conditioned Behavior Reinforced by Dopamine Neuron Activation Download full text (pdf) of Disrupting Glutamate Co-transmission Does Not Affect Acquisition of Conditioned Behavior Reinforced by Dopamine Neuron Activation

VGLUT2 genotype interacts with environmental experiences to predict alcohol misuse in young adults

Vrettou, Maria; Nillson, Kent W.; Tuvblad, Catherine; Rehn, Mattias et al.

2016.

Reduced Vglut2/Slc17a6 Gene Expression Levels throughout the Mouse Subthalamic Nucleus Cause Cell Loss and Structural Disorganization Followed by Increased Motor Activity and Decreased Sugar Consumption

Schweizer, Nadine; Viereckel, Thomas; Smith-Anttila, Casey J. A.; Nordenankar, Karin et al.

Part of eNeuro, 2016.

DOI for Reduced Vglut2/Slc17a6 Gene Expression Levels throughout the Mouse Subthalamic Nucleus Cause Cell Loss and Structural Disorganization Followed by Increased Motor Activity and Decreased Sugar Consumption

Midbrain Gene Screening Identifies a New Mesoaccumbal Glutamatergic Pathway and a Marker for Dopamine Cells Neuroprotected in Parkinson's Disease

Viereckel, Thomas; Dumas, Sylvie; Smith-Anttila, Casey J. A.; Vlcek, Bianca et al.

Part of Scientific Reports, 2016.

DOI for Midbrain Gene Screening Identifies a New Mesoaccumbal Glutamatergic Pathway and a Marker for Dopamine Cells Neuroprotected in Parkinson's Disease Download full text (pdf) of Midbrain Gene Screening Identifies a New Mesoaccumbal Glutamatergic Pathway and a Marker for Dopamine Cells Neuroprotected in Parkinson's Disease

In Situ Proximity Ligation Assay (PLA)

Bagchi, Sonchita; Fredriksson, Robert; Wallén-Mackenzie, Åsa

Part of ELISA, p. 149-159, 2015.

DOI for In Situ Proximity Ligation Assay (PLA)

Reply to Konsolaki and Skaliora: Habituation, hyperlocomotion, and "genuine hyperlocomotion"

Pupe, Stefano; Schweizer, Nadine; Wallen-Mackenzie, Åsa

Part of Proceedings of the National Academy of Sciences of the United States of America, p. E5-E5, 2015.

DOI for Reply to Konsolaki and Skaliora: Habituation, hyperlocomotion, and "genuine hyperlocomotion"

Increased hippocampal excitability and impaired spatial memory function in mice lacking VGLUT2 selectively in neurons defined by tyrosine hydroxylase promoter activity

Nordenankar, Karin; Smith-Anttila, Casey J A; Schweizer, Nadine; Viereckel, Thomas et al.

Part of Brain Structure and Function, p. 2171-2190, 2015.

DOI for Increased hippocampal excitability and impaired spatial memory function in mice lacking VGLUT2 selectively in neurons defined by tyrosine hydroxylase promoter activity Download full text (pdf) of Increased hippocampal excitability and impaired spatial memory function in mice lacking VGLUT2 selectively in neurons defined by tyrosine hydroxylase promoter activity

Targeted deletion of Vglut2 expression in the embryonal telencephalon promotes an anxiolytic phenotype of the adult mouse

Nordenankar, Karin; Bergfors, Assar; Wallén-Mackenzie, Åsa

Part of Upsala Journal of Medical Sciences, 2015.

DOI for Targeted deletion of Vglut2 expression in the embryonal telencephalon promotes an anxiolytic phenotype of the adult mouse Download full text (pdf) of Targeted deletion of Vglut2 expression in the embryonal telencephalon promotes an anxiolytic phenotype of the adult mouse

Ethanol Affects Limbic and Striatal Expression of Vesicular Glutamate Transporters in Outbred Rats Exposed to Early Life Stress

Vrettou, Maria; Granholm, Linnea; Todkar, Aniruddha; Nilsson, Kent W. et al.

Part of Alcohol and Alcoholism, 2015.

Cre-driven optogenetics in the heterogeneous genetic panorama of the VTA

Pupe, Stefano; Wallén-Mackenzie, Åsa

Part of TINS - Trends in Neurosciences, p. 375-386, 2015.

DOI for Cre-driven optogenetics in the heterogeneous genetic panorama of the VTA

SLC10A4 Is a Vesicular Amine-Associated Transporter Modulating Dopamine Homeostasis

Larhammar, Martin; Patra, Kalicharan; Blunder, Martina; Emilsson, Lina et al.

Part of Biological Psychiatry, p. 526-536, 2015.

DOI for SLC10A4 Is a Vesicular Amine-Associated Transporter Modulating Dopamine Homeostasis

Haplotype-tag single nucleotide polymorphism analysis of the Vesicular Glutamate Transporter (VGLUT) genes in severely alcoholic women

Comasco, Erika; Hallman, Jarmila; Wallen-Mackenzie, Åsa

Part of Psychiatry Research, p. 403-405, 2014.

DOI for Haplotype-tag single nucleotide polymorphism analysis of the Vesicular Glutamate Transporter (VGLUT) genes in severely alcoholic women

Reduced Gene Expression Levels of Munc13-1 and Additional Components of the Presynaptic Exocytosis Machinery Upon Conditional Targeting of Vglut2 in the Adolescent Mouse

Rajagopalan, Aparna; Schweizer, Nadine; Nordenankar, Karin; Jahan, Sultana Nilufar et al.

Part of Synapse, p. 624-633, 2014.

DOI for Reduced Gene Expression Levels of Munc13-1 and Additional Components of the Presynaptic Exocytosis Machinery Upon Conditional Targeting of Vglut2 in the Adolescent Mouse

The multilingual nature of dopamine neurons

Trudeau, Louis-Eric; Hnasko, Thomas S.; Wallén-Mackenzie, Åsa; Morales, Marisela et al.

Part of Dopamine, p. 141-164, 2014.

DOI for The multilingual nature of dopamine neurons

Limiting glutamate transmission in a Vglut2-expressing subpopulation of the subthalamic nucleus is sufficient to cause hyperlocomotion

Schweizer, Nadine; Pupe, Stefano; Arvidsson, Emma; Nordenankar, Karin et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 7837-7842, 2014.

DOI for Limiting glutamate transmission in a Vglut2-expressing subpopulation of the subthalamic nucleus is sufficient to cause hyperlocomotion

Age- and Sex-Dependence of Dopamine Release and Capacity for Recovery Identified in the Dorsal Striatum ofC57/Bl6J Mice

Arvidsson, Emma; Viereckel, Thomas; Mikulovic, Sanja; Wallén-Mackenzie, Åsa

Part of PLOS ONE, p. e99592-, 2014.

DOI for Age- and Sex-Dependence of Dopamine Release and Capacity for Recovery Identified in the Dorsal Striatum ofC57/Bl6J Mice Download full text (pdf) of Age- and Sex-Dependence of Dopamine Release and Capacity for Recovery Identified in the Dorsal Striatum ofC57/Bl6J Mice

Glutamate corelease promotes growth and survival of midbrain dopamine neurons

Fortin, G. M.; Bourque, M. -J; Mendez, J. A.; Leo, D. et al.

Part of Journal of Neuroscience, p. 17477-17491, 2012.

DOI for Glutamate corelease promotes growth and survival of midbrain dopamine neurons

Ultrastructural characterization of the mesostriatal dopamine innervation in mice, including two mouse lines of conditional VGLUT2 knockout in dopamine neurons

Berube-Carriere, Noemie; Guay, Ginette; Fortin, Guillaume M.; Kullander, Klas et al.

Part of European Journal of Neuroscience, p. 527-538, 2012.

DOI for Ultrastructural characterization of the mesostriatal dopamine innervation in mice, including two mouse lines of conditional VGLUT2 knockout in dopamine neurons

Haplotype tag single-nucleotide polymorphism analysis of the vesicular glutamate transporter 2 gene in severe alcoholism among women

Comasco, Erika; Oreland, Lars; Hallman, Jarmila; Wallen-Mackenzie, Åsa

Part of European Neuropsychopharmacology, p. S397-S397, 2012.

DOI for Haplotype tag single-nucleotide polymorphism analysis of the vesicular glutamate transporter 2 gene in severe alcoholism among women

Targeting VGLUT2 in dopamine neurons affects the brain reward system

Wallen-Mackenzie, Åsa; Arvidsson, Emma; Restrepo, Ernesto; Johann, Stefano Pupe et al.

Part of European Neuropsychopharmacology, p. S128-S129, 2012.

DOI for Targeting VGLUT2 in dopamine neurons affects the brain reward system

From glutamate co-release to vesicular synergy: vesicular glutamate transporters

El Mestikawy, Salah; Wallén-Mackenzie, Åsa; Fortin, Guillaume M.; Descarries, Laurent et al.

Part of Nature Reviews Neuroscience, p. 204-216, 2011.

DOI for From glutamate co-release to vesicular synergy: vesicular glutamate transporters

A sensory subpopulation depends on vesicular glutamate transporter 2 for mechanical pain, and together with substance P, inflammatory pain

Lagerström, Malin C.; Rogoz, Katarzyna; Abrahamsen, Bjarke; Lind, Anne-Li et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 5789-5794, 2011.

DOI for A sensory subpopulation depends on vesicular glutamate transporter 2 for mechanical pain, and together with substance P, inflammatory pain

Enhanced Sucrose and Cocaine Self-Administration and Cue-Induced Drug Seeking after Loss of VGLUT2 in Midbrain Dopamine Neurons in Mice

Alsiö, Johan; Nordenankar, Karin; Arvidsson, Emma; Birgner, Carolina et al.

Part of Journal of Neuroscience, p. 12593-12603, 2011.

DOI for Enhanced Sucrose and Cocaine Self-Administration and Cue-Induced Drug Seeking after Loss of VGLUT2 in Midbrain Dopamine Neurons in Mice

Genetic inactivation of the vesicular glutamate transporter 2 (VGLUT2) in the mouse: what have we learnt about functional glutamatergic neurotransmission?

Wallén-Mackenzie, Åsa; Wootz, Hanna; Englund, Hillevi

Part of Upsala Journal of Medical Sciences, p. 11-20, 2010.

DOI for Genetic inactivation of the vesicular glutamate transporter 2 (VGLUT2) in the mouse: what have we learnt about functional glutamatergic neurotransmission?

VGLUT2-Dependent Sensory Neurons in the TRPV1 Population Regulate Pain and Itch

Lagerström, Malin C.; Rogoz, Katarzyna; Abrahamsen, Bjarke; Persson, Emma et al.

Part of Neuron, p. 529-542, 2010.

DOI for VGLUT2-Dependent Sensory Neurons in the TRPV1 Population Regulate Pain and Itch

VGLUT2 in dopamine neurons is required for psychostimulant-induced behavioural activation

Birgner, Carolina; Nordenankar, Karin; Lundblad, Martin; Mendez, José Alfredo et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 389-394, 2010.

DOI for VGLUT2 in dopamine neurons is required for psychostimulant-induced behavioural activation

Reduced VGLUT2 expression increases motor neuron viability in Sod1(G93A) mice

Wootz, Hanna; Enjin, Anders; Wallen-Mackenzie, Åsa; Lindholm, Dan et al.

Part of Neurobiology of Disease, p. 58-66, 2010.

DOI for Reduced VGLUT2 expression increases motor neuron viability in Sod1(G93A) mice

Restricted cortical and amygdaloid removal of vesicular glutamate transporter 2 in preadolescent mice impacts dopaminergic activity and neuronal circuitry of higher brain function

Wallén-Mackenzie, Åsa; Nordenankar, Karin; Fejgin, Kim; Lagerström, Malin C et al.

Part of Journal of Neuroscience, p. 2238-2251, 2009.

DOI for Restricted cortical and amygdaloid removal of vesicular glutamate transporter 2 in preadolescent mice impacts dopaminergic activity and neuronal circuitry of higher brain function

VGLUT2 is essential in neuronal circuitry of cognitive and emotional behavior

Mackenzie, Åsa; Fejgin, Kim; Lagerström, Malin C; Nordenankar, Karin et al.

Part of Society for Neuroscience Abstract Viewer and Itinerary Planner, 2008.

Vesicular glutamate transporter 2 is required for central respiratory rhythm generation but not for locomotor central pattern generation

Wallén-Mackenzie, Åsa; Gezelius, Henrik; Thoby-Brisson, Muriel; Nygård, Anna et al.

Part of Journal of Neuroscience, p. 12294-12307, 2006.

DOI for Vesicular glutamate transporter 2 is required for central respiratory rhythm generation but not for locomotor central pattern generation

Role of glutamate in locomotor rhythm generating neuronal circuitry

Gezelius, Henrik; Wallén-Mackenzie, Åsa; Enjin, Anders; Lagerström, Malin et al.

Part of Journal of Physiology - Paris, p. 297-303, 2006.

DOI for Role of glutamate in locomotor rhythm generating neuronal circuitry